Mantle cell lymphoma (MCL) is a distinct subtype of B-cell non-hodgkin lymphoma. It is due to a chromosomal translocation resulting in the overexpression of cyclin D1 gene. The clinical features and growth pattern hinder the recognition of the disease because it has a range of morphologic and growth patterns so a specific marker is important for a correct diagnosis. We report a case of a 58 years old female with a left tonsillar mantle cell lymphoma diagnosed by biopsy of the lesion. The patient underwent chemotherapy with a relapse at two years follow-up.
In conclusion in a monolateral tonsillar hyperplasia in an adult immunohistochemical staining is mandatory in the process of recognizing mantle cell lymphoma due to the confusion that could be made with other similar diseases such as chronic lymphocytic leukemia or small lymphocytic lymphoma and follicular lymphoma.