The Genetics of Chronic Otitis Media

Rate this item
(0 votes)

Chronic otitis media is the major reason for middle ear surgery. Epidemiological studies have revealed high heritability of persistent or recurrent middle ear inflammation. The genetic basis of chronic otitis media is complex, but a number of methods can be used to interrogate this complexity. The most promising method is the identification of genetic mutant mouse models, which may highlight genes to test for association with human disease, and enable pathobiology to be explored. Such an approach has suggested that the gene FBXO11 is associated with susceptibility to otitis media in man, and has also suggested that hypoxia signaling is an important component of the chronically inflamed middle ear. We discuss future research strategies in this field.

Additional Info

Read 1519 times

Leave a comment

Make sure you enter the (*) required information where indicated. HTML code is not allowed.

Search

Member Login

          Forgot login? | Register

BBC News Feed

Get in touch

Tel:
+44 207 637 3544

Email:
This email address is being protected from spambots. You need JavaScript enabled to view it.

Address:
The Otorhinolaryngologist,
73 Newman Street, London
W1T 3EJ, 
UK

 

Rila Publications Ltd Ethics Policy